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FP-1039   Click here for help

GtoPdb Ligand ID: 11581

Synonyms: FGFR1:Fc | FP1039 | GSK-3052230 | GSK3052230 | HGS1036
Compound class: Peptide
Comment: FP-1039 (GSK3052230) is a fusion protein that comprises the extracellular domain of FGF receptor 1c (FGFR1c; to act as a trap for FGF ligands) fused with the Fc region of IgG1. The full peptide sequence is not disclosed in the primary citation [1]. FP-1039 is an oncology lead candidate [1,3].
Bioactivity Comments
BInding affinities for mitogenic FGF ligands is available in Table 1 (Harding et al., 2013) [1].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
FGF-1 Hs None Binding 10.5 pKi - 1
⤷ pKi 10.5 (Ki 3x10-11 M) [1]
Description: Binding affinity determined by SPR analysis