P2X receptors: Introduction

ATP acting via P2 receptors (P2Y and P2X family members) serves as an essential mediator of functional responses in human eosinophils [2], responses which may be implicated in the pathogenesis of various forms of airway inflammation [3]. Potential targeting of purinergic receptors for the treatment of gout and fibrosis is reviewed in [1].

References

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1. Gicquel T, Le Daré B, Boichot E, Lagente V. (2017) Purinergic receptors: new targets for the treatment of gout and fibrosis. Fundam Clin Pharmacol, 31 (2): 136-146. [PMID:27885718]

2. Kobayashi T, Soma T, Noguchi T, Nakagome K, Nakamoto H, Kita H, Nagata M. (2015) ATP drives eosinophil effector responses through P2 purinergic receptors. Allergol Int, 64 Suppl: S30-6. [PMID:26344078]

3. Pelleg A, Schulman ES, Barnes PJ. (2016) Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases. Chest, 150 (4): 908-915. [PMID:27568579]

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