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Neuropilins and Plexins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Neuropilins act as receptors for class 3 (secreted) semaphorins; Plexins are receptors for class 4, 5 and 6 (transmembrane) semaphorins and are signalling partners for class 3 semaphorins. The semaphorins and their receptors participate in numerous and diverse biological processes including neural development, immunology/inflammation, cardiac growth, vascular development, lung morphogenesis, and axial bone patterning.


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Targets of relevance to immunopharmacology are highlighted in blue

neuropilin 1 Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Neuropilins and Plexins. Accessed on 02/10/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.