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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Chitinase 1 (CHIT1) and acidic mammalian chitinase (CHIA; AMCase) are the enzymatically active chitinases that are part of a key pathway in tissue remodeling, and which have been implicated in the pathology of chronic fibrotic lung diseases. Small molecule chitinase inhibitors are being investigated for anti-fibrotic efficacy in idiopathic pulmonary fibrosis (IPF) and offer potential for other diseases with a fibrotic component.


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Targets of relevance to immunopharmacology are highlighted in blue

AMCase (chitinase acidic) Show summary » More detailed page go icon to follow link

chitinase 1 Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

Chitinases. Accessed on 04/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.