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3C. 3-Ketosteroid receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [6,18]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone).


Targets of relevance to immunopharmacology are highlighted in blue

Androgen receptor / NR3C4 C Show summary » More detailed page

Glucocorticoid receptor / NR3C1 C Show summary » More detailed page

Mineralocorticoid receptor / NR3C2 C Show summary » More detailed page

Progesterone receptor / NR3C3 C Show summary » More detailed page


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Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Derek Cain, John Cidlowski, Dean P. Edwards, Peter Fuller, Sandra L. Grimm, Sean Hartig, Carol A. Lange, Robert H. Oakley, Jennifer K. Richer, Carol A. Sartorius, Marc Tetel, Nancy Weigel, Morag Young. 3C. 3-Ketosteroid receptors. Accessed on 26/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Nuclear hormone receptors. Br J Pharmacol. 174 Suppl 1: S208-S224.