2E. Tailless-like receptors | Nuclear hormone receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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2E. Tailless-like receptors

2E. Tailless-like receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Tailless-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1]) have yet to be officially paired with an endogenous ligand.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

TLX / NR2E1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

615

Nomenclature

TLX

Systematic nomenclature

NR2E1

Previous and unofficial names

Genes

NR2E1 (Hs), Nr2e1 (Mm), Nr2e1 (Rn)

Ensembl ID

ENSG00000112333 (Hs), ENSMUSG00000019803 (Mm), ENSRNOG00000050550 (Rn)

UniProtKB AC

Q9Y466 (Hs), Q64104 (Mm)

Agonists

tretinoin [2]

BMS493 [2]

Comment

Gene disruption is associated with abnormal brain development [3-4].

PNR / NR2E3 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	616
Nomenclature	PNR
Systematic nomenclature	NR2E3
Previous and unofficial names	nuclear receptor subfamily 2 \| nuclear receptor subfamily 2, group E, member 3 \| Photoreceptor-specific nuclear receptor \| rd7 \| retina-specific nuclear receptor \| RNR \| RP37
Genes	NR2E3 (Hs), Nr2e3 (Mm)
Ensembl ID	ENSG00000278570 (Hs), ENSMUSG00000032292 (Mm)
UniProtKB AC	Q9Y5X4 (Hs), Q9QXZ7 (Mm)

References

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1. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev, 58 (4): 798-836. [PMID:17132856]

2. Griffett K, Bedia-Diaz G, Hegazy L, de Vera IMS, Wanninayake US, Billon C, Koelblen T, Wilhelm ML, Burris TP. (2020) The Orphan Nuclear Receptor TLX Is a Receptor for Synthetic and Natural Retinoids. Cell Chem Biol, 27 (10): 1272-1284.e4. [PMID:32763139]

3. Land PW, Monaghan AP. (2003) Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Cereb Cortex, 13 (9): 921-31. [PMID:12902391]

4. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. (1997) Defective limbic system in mice lacking the tailless gene. Nature, 390 (6659): 515-7. [PMID:9394001]

How to cite this family page

Database page citation:

2E. Tailless-like receptors. Accessed on 31/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=94.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors. Br J Pharmacol. 180 Suppl 2:S223-240.