2E. Tailless-like receptors | Nuclear hormone receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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2E. Tailless-like receptors

2E. Tailless-like receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Tailless-like receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1]) have yet to be officially paired with an endogenous ligand.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

TLX / NR2E1 C Show summary »« Hide summary More detailed page

Target Id	615
Nomenclature	TLX
Systematic nomenclature	NR2E1
Previous and unofficial names	tailless homologue \| TLL \| Mtll \| frc \| XTLL \| nuclear receptor subfamily 2
Genes	NR2E1 (Hs), Nr2e1 (Mm), Nr2e1 (Rn)
Ensembl ID	ENSG00000112333 (Hs), ENSMUSG00000019803 (Mm), ENSRNOG00000050550 (Rn)
UniProtKB AC	Q9Y466 (Hs), Q64104 (Mm)
Comment	Gene disruption is associated with abnormal brain development [2-3].

PNR / NR2E3 C Show summary »« Hide summary More detailed page

Target Id	616
Nomenclature	PNR
Systematic nomenclature	NR2E3
Previous and unofficial names	nuclear receptor subfamily 2 \| nuclear receptor subfamily 2, group E, member 3 \| Photoreceptor-specific nuclear receptor \| rd7 \| retina-specific nuclear receptor \| RNR \| RP37
Genes	NR2E3 (Hs), Nr2e3 (Mm)
Ensembl ID	ENSG00000031544 (Hs), ENSMUSG00000032292 (Mm)
UniProtKB AC	Q9Y5X4 (Hs), Q9QXZ7 (Mm)

References

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1. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. (2006) International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol. Rev., 58 (4): 798-836. [PMID:17132856]

2. Land PW, Monaghan AP. (2003) Expression of the transcription factor, tailless, is required for formation of superficial cortical layers. Cereb. Cortex, 13 (9): 921-31. [PMID:12902391]

3. Monaghan AP, Bock D, Gass P, Schwäger A, Wolfer DP, Lipp HP, Schütz G. (1997) Defective limbic system in mice lacking the tailless gene. Nature, 390 (6659): 515-7. [PMID:9394001]

How to cite this family page

Database page citation:

2E. Tailless-like receptors. Accessed on 04/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=94.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br J Pharmacol. 176 Issue S1: S229-S246.