GRK4 subfamily | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Enzymes
Kinases (EC 2.7.x.x)
AGC: Containing PKA, PKG, PKC families
G protein-coupled receptor kinases (GRKs)
GRK4 subfamily

GRK4 subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

GRK4 (G protein-coupled receptor kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

GRK5 (G protein-coupled receptor kinase 5) Show summary »« Hide summary More detailed page go icon to follow link

GRK6 (G protein-coupled receptor kinase 6) Show summary »« Hide summary More detailed page go icon to follow link

References

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1. Cho SY, Lee BH, Jung H, Yun CS, Ha JD, Kim HR, Chae CH, Lee JH, Seo HW, Oh KS. (2013) Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett, 23 (24): 6711-6. [PMID:24210504]

2. Pronin AN, Benovic JL. (1997) Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J Biol Chem, 272 (6): 3806-12. [PMID:9013639]

3. Sallese M, Mariggiò S, Collodel G, Moretti E, Piomboni P, Baccetti B, De Blasi A. (1997) G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. J Biol Chem, 272 (15): 10188-95. [PMID:9092566]

How to cite this family page

Database page citation:

GRK4 subfamily. Accessed on 11/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=937.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.