LPA synthesis

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LPA synthesis

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

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autotaxin Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2901

Nomenclature

autotaxin

Previous and unofficial names

ATX | PDNP2 | PD-IALPHA | lysoPLD

Genes

ENPP2 (Hs), Enpp2 (Mm), Enpp2 (Rn)

Ensembl ID

ENSG00000136960 (Hs), ENSMUSG00000022425 (Mm), ENSRNOG00000004089 (Rn)

UniProtKB AC

Q13822 (Hs), Q9R1E6 (Mm), Q64610 (Rn)

EC number

3.1.4.39
Hydrolysis of lysophosphatidylcholine to form lysophosphatidic acid 1-alkyl-sn-glycero-3-phosphoethanolamine + H₂O <=> 1-alkyl-sn-glycerol 3-phosphate + ethanolamine

Comment

Autotaxin is an extracellular multifunctional enzyme. Its lysophospholipase D activity hydrolyzes lysophosphatidylcholine to form the bioactive lipid lysophosphatidic acid (LPA). Autotaxin is considered to be the main source of LPA in vivo. It also acts on other substrates to produce additional bioactive lipids, for example generating sphingosine-1-phosphate (S1P) from sphingosylphosphorylcholine [1].

References

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How to cite this family page

Database page citation:

LPA synthesis. Accessed on 08/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=928.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.