Top ▲ Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.


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Targets of relevance to immunopharmacology are highlighted in blue

isocitrate dehydrogenase (NADP(+)) 1 / IDH1 C Show summary » More detailed page go icon to follow link

isocitrate dehydrogenase (NADP(+)) 2 / IDH2 C Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation: Isocitrate dehydrogenases. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.