1.1.1.42 Isocitrate dehydrogenases

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1.1.1.42 Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

isocitrate dehydrogenase (NADP(+)) 1 / IDH1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2884

Nomenclature

isocitrate dehydrogenase (NADP(+)) 1

Systematic nomenclature

IDH1

Previous and unofficial names

isocitrate dehydrogenase 1 (NADP) | isocitrate dehydrogenase 1 (NADP+) | isocitrate dehydrogenase 1 (NADP+), soluble | isocitrate dehydrogenase (NADP(+)) 1, cytosolic | isocitrate dehydrogenase [NADP] cytoplasmic

Genes

IDH1 (Hs), Idh1 (Mm), Idh1 (Rn)

Ensembl ID

ENSG00000138413 (Hs), ENSMUSG00000025950 (Mm), ENSRNOG00000015020 (Rn)

UniProtKB AC

O75874 (Hs), O88844 (Mm), P41562 (Rn)

EC number

1.1.1.42	Isocitrate + NADP(+) <=> 2-oxoglutarate + CO₂ + NADPH
Isocitrate + NADP+ <=> 2-oxoglutarate + CO₂ + NADPH

Inhibitors

AGI-5198 pK_i 4.9

Selective inhibitors

ivosidenib [1]

isocitrate dehydrogenase (NADP(+)) 2 / IDH2 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2885
Nomenclature	isocitrate dehydrogenase (NADP(+)) 2
Systematic nomenclature	IDH2
Previous and unofficial names	IDH-2 \| IDPm \| isocitrate dehydrogenase 2 (NADP+) \| isocitrate dehydrogenase 2 (NADP+), mitochondrial \| isocitrate dehydrogenase 2 (NADP), mitochondrial \| isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Genes	IDH2 (Hs), Idh2 (Mm), Idh2 (Rn)
Ensembl ID	ENSG00000182054 (Hs), ENSMUSG00000030541 (Mm), ENSRNOG00000013949 (Rn)
UniProtKB AC	P48735 (Hs), P54071 (Mm), P56574 (Rn)

References

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How to cite this family page

Database page citation:

1.1.1.42 Isocitrate dehydrogenases. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=922.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.