Top ▲

Nucleoside synthesis and metabolism C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The de novo synthesis and salvage of nucleosides have been targetted for therapeutic advantage in the treatment of particular cancers and gout. Dihydrofolate reductase produces tetrahydrofolate, a cofactor required for synthesis of purines, pyrimidines and amino acids. GART allows formylation of phosphoribosylglycinamide, an early step in purine biosynthesis. Dihydroorotate dehydrogenase produces orotate, a key intermediate in pyrimidine synthesis. IMP dehydrogenase generates xanthosine monophosphate, an intermediate in GTP synthesis.

Enzymes

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

DHFR (dihydrofolate reductase) C Show summary » More detailed page go icon to follow link

GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase) C Show summary » More detailed page go icon to follow link

DHODH (dihydroorotate dehydrogenase (quinone)) C Show summary » More detailed page go icon to follow link

IMPDH1 (inosine monophosphate dehydrogenase 1) C Show summary » More detailed page go icon to follow link

IMPDH2 (inosine monophosphate dehydrogenase 2) C Show summary » More detailed page go icon to follow link

TYMS (thymidylate synthetase) C Show summary » More detailed page go icon to follow link

PNP (purine nucleoside phosphorylase) C Show summary » More detailed page go icon to follow link

XDH (xanthine dehydrogenase) C Show summary » More detailed page go icon to follow link

ribonucleotide reductase M1 (ribonucleotide reductase catalytic subunit M1) C Show summary » More detailed page go icon to follow link

ribonucleotide reductase M2 (ribonucleotide reductase regulatory subunit M2) C Show summary » More detailed page go icon to follow link

ribonucleotide reductase M2B (TP53 inducible) (ribonucleotide reductase regulatory TP53 inducible subunit M2B) C Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=920.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.