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2B. Retinoid X receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Retinoid X receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [5]) are NR2B family members activated by alitretinoin and the RXR-selective agonists bexarotene and LG100268, sometimes referred to as rexinoids. UVI3003 [8] and HX 531 [4] have been described as a pan-RXR antagonists. These receptors form RXR-RAR heterodimers and RXR-RXR homodimers [3,7].

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

Retinoid X receptor-α / NR2B1 C Show summary » More detailed page

Retinoid X receptor-β / NR2B2 C Show summary » More detailed page

Retinoid X receptor-γ / NR2B3 C Show summary » More detailed page

Further reading

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References

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How to cite this family page

Database page citation:

2B. Retinoid X receptors. Accessed on 19/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=92.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br J Pharmacol. 176 Issue S1: S229-S246.