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2A. Hepatocyte nuclear factor-4 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [5]. HNF4γ has yet to be paired with an endogenous ligand.


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Targets of relevance to immunopharmacology are highlighted in blue

Hepatocyte nuclear factor-4-α / NR2A1 C Show summary » More detailed page go icon to follow link

Hepatocyte nuclear factor-4-γ / NR2A2 C Show summary » More detailed page go icon to follow link

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors. Br J Pharmacol. 178 Suppl 1:S246-S263.