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2A. Hepatocyte nuclear factor-4 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]. While linoleic acid has been identified as the endogenous ligand for HNF4α its function remains ambiguous [5]. HNF4γ has yet to be paired with an endogenous ligand.


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Targets of relevance to immunopharmacology are highlighted in blue

Hepatocyte nuclear factor-4-α / NR2A1 C Show summary » More detailed page go icon to follow link

Hepatocyte nuclear factor-4-γ / NR2A2 C Show summary » More detailed page go icon to follow link

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Nuclear hormone receptors. Br J Pharmacol. 176 Issue S1: S229-S246.