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Serum pentraxins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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SAP is a member of the pentraxin protein family.

SAP [7] is a constitutively expressed vertebrate protein [9] found in all types of amyloid deposits [10-11], in glomerular basement membrane [3] and in elastic fibres in blood vessels [2]. SAP binding is calcium-dependent [8]. It is suggested that SAP binding may have an important role to play in atherosclerosis [6,12] and amyloidosis [1,14]. The identification of SAP as a player in amyloidoses and neuropathies, and in response to proof of concept studies [4], this protein is now a drug discovery target [5].


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Targets of relevance to immunopharmacology are highlighted in blue

amyloid P component, serum Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

Serum pentraxins. Accessed on 21/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.