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1F. Retinoic acid-related orphans C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Retinoic acid receptor-related orphan receptors (ROR, nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [1-2]) have yet to be assigned a definitive endogenous ligand, although RORα may be synthesized with a ‘captured’ agonist such as cholesterol [6-7].

Receptors

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Targets of relevance to immunopharmacology are highlighted in blue

RAR-related orphan receptor-α / NR1F1 C Show summary » More detailed page go icon to follow link

RAR-related orphan receptor-β / NR1F2 C Show summary » More detailed page go icon to follow link

RAR-related orphan receptor-γ / NR1F3 C Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Cidlowski JA, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors. Br J Pharmacol. 180 Suppl 2:S223-240.