Kelch-like proteins
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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More detailed introduction 
Keap1 is involved in the Keap1-Nrf2-ARE signaling pathway that is essential for protecting cells from oxidative stress. Nrf2 = nuclear factor erythroid 2-related factor 2; ARE = antioxidant response elements.
Targets
Targets of relevance to immunopharmacology are highlighted in blue
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kelch like ECH-associated protein 1
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How to cite this family page
Database page citation:
Kelch-like proteins. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=876.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.
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