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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [16], and family members have been targetted for immunosuppressant effects.
FKBP12 (FKBP prolyl isomerase 1A)
C
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FKBP38 (FKBP prolyl isomerase 8) C
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FKBP51 (FKBP prolyl isomerase 5) C
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FKBP52 (FKBP prolyl isomerase 4) C
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FKBP prolyl isomerase like C
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peptidylprolyl cis/trans isomerase, NIMA-interacting 1
C
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peptidylprolyl isomerase A
C
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cyclophilin D (peptidylprolyl isomerase D) C
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Database page citation:
Stephanie Annett, Tracy Robson. Peptidyl-prolyl cis/trans isomerases. Accessed on 12/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=845.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.