5.2.-.- Cis-trans-isomerases

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5.2.-.- Cis-trans-isomerases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

FKBP prolyl isomerase 1A Show summary »« Hide summary More detailed page

Target Id

2609

Nomenclature

FKBP prolyl isomerase 1A

Previous and unofficial names

Genes

FKBP1A (Hs), Fkbp1a (Mm), Fkbp1a (Rn)

Ensembl ID

ENSG00000088832 (Hs), ENSMUSG00000032966 (Mm), ENSRNOG00000008822 (Rn)

UniProtKB AC

P62942 (Hs), P26883 (Mm), Q62658 (Rn)

EC number

5.2.1.8

Inhibitors

zotarolimus (Binding) pIC₅₀ 8.6 [1]

Selective inhibitors

tacrolimus pK_i 9.4 [2]

pimecrolimus pIC₅₀ 8.2 [3] - Rat

peptidylprolyl isomerase A Show summary »« Hide summary More detailed page

References

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1. Garcia-Touchard A, Burke SE, Toner JL, Cromack K, Schwartz RS. (2006) Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks. Eur. Heart J., 27 (8): 988-93. [PMID:16449248]

2. Hamilton GS, Steiner JP. (1998) Immunophilins: beyond immunosuppression. J. Med. Chem., 41 (26): 5119-43. [PMID:9857082]

3. Hultsch T, Müller KD, Meingassner JG, Grassberger M, Schopf RE, Knop J. (1998) Ascomycin macrolactam derivative SDZ ASM 981 inhibits the release of granule-associated mediators and of newly synthesized cytokines in RBL 2H3 mast cells in an immunophilin-dependent manner. Arch. Dermatol. Res., 290 (9): 501-7. [PMID:9808344]

How to cite this family page

Database page citation:

5.2.-.- Cis-trans-isomerases. Accessed on 13/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=845.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.