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Peptidyl-prolyl cis/trans isomerases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Peptidyl-prolyl cis/trans isomerases (PPIases) are an enzyme family which catalyse the cis/trans isomerisation of proline peptide bonds to promote the folding and re-folding of peptides and proteins. Three subfamilies have been identified: cyclophilins, FK506-binding proteins and parvulins. Individual PPIases are overexpressed in a number of cancers [16], and family members have been targetted for immunosuppressant effects.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

FKBP12 (FKBP prolyl isomerase 1A) C Show summary » More detailed page go icon to follow link

FKBP38 (FKBP prolyl isomerase 8) C Show summary » More detailed page go icon to follow link

FKBP51 (FKBP prolyl isomerase 5) C Show summary » More detailed page go icon to follow link

FKBP52 (FKBP prolyl isomerase 4) C Show summary » More detailed page go icon to follow link

FKBP prolyl isomerase like C Show summary » More detailed page go icon to follow link

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 C Show summary » More detailed page go icon to follow link

Cyclophilin A (peptidylprolyl isomerase A) C Show summary » More detailed page go icon to follow link

Cyclophilin D (peptidylprolyl isomerase D) C Show summary » More detailed page go icon to follow link

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.