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Ceramide synthase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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This family of enzymes, also known as sphingosine N-acyltransferase, is located in the ER facing the cytosol with an as-yet undefined topology and stoichiometry. Ceramide synthase in vitro is sensitive to inhibition by the fungal derived toxin, fumonisin B1.


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Targets of relevance to immunopharmacology are highlighted in blue

CERS1 (ceramide synthase 1) C Show summary »

CERS2 (ceramide synthase 2) C Show summary »

CERS3 (ceramide synthase 3) C Show summary »

CERS4 (ceramide synthase 4) C Show summary »

CERS5 (ceramide synthase 5) C Show summary »

CERS6 (ceramide synthase 6) C Show summary »


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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.