Ceramide glucosyltransferase | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Home
Targets
Enzymes
Ceramide turnover
Ceramide glucosyltransferase

Ceramide glucosyltransferase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

UDP-glucose ceramide glucosyltransferase C Show summary »« Hide summary More detailed page

Target Id

2528

Nomenclature

UDP-glucose ceramide glucosyltransferase

Previous and unofficial names

Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl

Genes

UGCG (Hs), Ugcg (Mm), Ugcg (Rn)

Ensembl ID

ENSG00000148154 (Hs), ENSMUSG00000028381 (Mm), ENSRNOG00000015644 (Rn)

UniProtKB AC

Q16739 (Hs), O88693 (Mm), Q9R0E0 (Rn)

EC number

2.4.1.80

UDP-glucose + ceramide = uridine diphosphate + glucosylceramide

Inhibitors

miglustat pK_i 5.1 [1]

Comment

Glycoceramides are an extended family of sphingolipids, differing in the content and organization of the sugar moieties, as well as the acyl sidechains.

References

Show »« Hide

How to cite this family page

Database page citation:

Ceramide glucosyltransferase. Accessed on 22/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=775.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.