Ceramide glucosyltransferase | Enzymes | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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Ceramide turnover
Ceramide glucosyltransferase

Ceramide glucosyltransferase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

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UDP-glucose ceramide glucosyltransferase C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2528

Nomenclature

UDP-glucose ceramide glucosyltransferase

Previous and unofficial names

Epcs21 | GCS | GLCT-1 | Glucosylceramide synthase | Ugcgl

Genes

UGCG (Hs), Ugcg (Mm), Ugcg (Rn)

Ensembl ID

ENSG00000148154 (Hs), ENSMUSG00000028381 (Mm), ENSRNOG00000015644 (Rn)

UniProtKB AC

Q16739 (Hs), O88693 (Mm), Q9R0E0 (Rn)

EC number

2.4.1.80

UDP-glucose + ceramide = uridine diphosphate + glucosylceramide

Inhibitors

miglustat pK_i 5.1 [1]

Comment

Glycoceramides are an extended family of sphingolipids, differing in the content and organization of the sugar moieties, as well as the acyl sidechains.

References

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.