Top ▲

T1: Proteasome C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The T1 macropain beta subunits form the catalytic proteinase core of the 20S proteasome complex [1]. This catalytic core enables the degradation of peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the cleavage site. The β5 subunit is the principal target of the approved drug proteasome inhibitor bortezomib.

Enzymes

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

proteasome 20S subunit beta 1 Show summary » More detailed page go icon to follow link

proteasome 20S subunit beta 2 Show summary » More detailed page go icon to follow link

proteasome 20S subunit beta 5 C Show summary » More detailed page go icon to follow link

proteasome 20S subunit beta 6 Show summary » More detailed page go icon to follow link

proteasome 20S subunit beta 8 Show summary » More detailed page go icon to follow link

proteasome 20S subunit beta 9 Show summary » More detailed page go icon to follow link

References

Click here for help

Show »

How to cite this family page

Database page citation:

T1: Proteasome. Accessed on 04/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=752.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.