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Phosphatidylinositol-4,5-bisphosphate 3-kinase family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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PI3K activation is one of the most important signal transduction pathways used to transmit signals from cell-surface receptors to regulate intracellular processes (cell growth, survival, proliferation and movement). PI3K catalytic (and regulatory) subunits play vital roles in normal cell function and in disease. Progress made in developing PI3K-targeted agents as potential therapeutics for treating cancer and other diseases is reviewed by Fruman et al. (2017) [4].


Targets of relevance to immunopharmacology are highlighted in blue

PI3Kα (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) C Show summary » More detailed page

PI3Kβ (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) C Show summary » More detailed page

PI3Kγ (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma) C Show summary » More detailed page

PI3Kδ (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) C Show summary » More detailed page


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.