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Src family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Activation of Src-family kinases leads to both stimulatory and inhibitory signaling responses, with cell-specific and signaling pathway-specific outcomes and redundancy of kinase function.

Immune system:
In immune cells Src kinases are involved in many signalling pathways, including ITAM- and ITIM-domain-containing receptor signaling, integrin signaling, and responses to chemokines/chemoattractants, cytokines, innate immune stimuli and a large variety of non-immune cell specific stimuli (UV irradiation, heat, osmotic shock etc.). In many cases Src kinases signal to MAP kinase or NF-κB pathways, but they can also modulate other pathways through less well characterized mechanisms.

The primary T cell Src kinases are Lck and Fyn; the main B cell Srcs are Lyn, Fyn and Blk. Mast cells express Fyn and Lyn, with low expression of Src.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

Blk (BLK proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page go icon to follow link

Fgr (FGR proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page go icon to follow link

FRK (fyn related Src family tyrosine kinase) C Show summary » More detailed page go icon to follow link

Fyn (FYN proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page go icon to follow link

Hck (HCK proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page go icon to follow link

Lck (LCK proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page go icon to follow link

Lyn (LYN proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page go icon to follow link

Brk (protein tyrosine kinase 6) Show summary » More detailed page go icon to follow link

Src (SRC proto-oncogene, non-receptor tyrosine kinase) C Show summary » More detailed page go icon to follow link

Srm (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) Show summary » More detailed page go icon to follow link

Yes (YES proto-oncogene 1, Src family tyrosine kinase) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Src family. Accessed on 15/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=619.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.