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Src family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Activation of Src-family kinases leads to both stimulatory and inhibitory signaling responses, with cell-specific and signaling pathway-specific outcomes and redundancy of kinase function.

Immune system:
In immune cells Src kinases are involved in many signalling pathways, including ITAM- and ITIM-domain-containing receptor signaling, integrin signaling, and responses to chemokines/chemoattractants, cytokines, innate immune stimuli and a large variety of non-immune cell specific stimuli (UV irradiation, heat, osmotic shock etc.). In many cases Src kinases signal to MAP kinase or NF-κB pathways, but they can also modulate other pathways through less well characterized mechanisms.

The primary T cell Src kinases are Lck and Fyn; the main B cell Srcs are Lyn, Fyn and Blk. Mast cells express Fyn and Lyn, with low expression of Src.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

Blk (BLK proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page

Fgr (FGR proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page

FRK (fyn related Src family tyrosine kinase) C Show summary » More detailed page

Fyn (FYN proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page

Hck (HCK proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page

Lck (LCK proto-oncogene, Src family tyrosine kinase) Show summary » More detailed page

Lyn (LYN proto-oncogene, Src family tyrosine kinase) C Show summary » More detailed page

Brk (protein tyrosine kinase 6) Show summary » More detailed page

Src (SRC proto-oncogene, non-receptor tyrosine kinase) C Show summary » More detailed page

Srm (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites) Show summary » More detailed page

Yes (YES proto-oncogene 1, Src family tyrosine kinase) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Src family. Accessed on 19/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=619.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.