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Polo-like kinase (PLK) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The Polo-like kinases (PLK) are Ser/Thr kinases of the cell cycle that are involved in regulating mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis [1,6]. PLK inhibitors are predicted to offer anti-proliferative potential for application in oncology [7,10].

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

PLK1 (polo like kinase 1) Show summary » More detailed page go icon to follow link

PLK2 (polo like kinase 2) Show summary » More detailed page go icon to follow link

PLK3 (polo like kinase 3) Show summary » More detailed page go icon to follow link

PLK4 (polo like kinase 4) C Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Polo-like kinase (PLK) family. Accessed on 04/10/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=602.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.