Top ▲

IKK family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

The IκB kinase (IKK)-related kinases are central to the induction of the innate type I interferon (IFN) response [8]. A set of rare autoimmune disorders known as type I interferonopathies are caused by disturbance of the homeostatic control of induction, transmission, and resolution of the type I IFN-mediated immune response [7]. Therefore, members of this signaling pathway are subject to investigation as intervention points for pharmacological inhibition [5]. Initial investigations targeted IFN-I downstream signaling, including IFN-I proteins, IFNAR and the JAK/STAT signaling pathway. For example, sifalimumab (anti-IFN-α mAb), anifrolumab (anti-IFNAR1) and the JAK inhibitors ruxolitinib and tofacitinib, can all potentially tackle the effector function of dysregulated IFN by blocking downstream IFN-I signaling, but do not contribute to reducing the production of IFN. Upstream targeting of TBK1 and/or IKKε could be effective at blocking de novo IFN-I induction by a variety of stimuli. Small molecule kinase inhibitors of TBK1/IKKε already in development for cancer may expedite investigation for inflammatory diseases also [10].

Enzymes

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

IKK-alpha (component of inhibitor of nuclear factor kappa B kinase complex) Show summary » More detailed page go icon to follow link

IKK-beta (inhibitor of nuclear factor kappa B kinase subunit beta) Show summary » More detailed page go icon to follow link

IKK-epsilon (inhibitor of nuclear factor kappa B kinase subunit epsilon) Show summary » More detailed page go icon to follow link

TBK1 (TANK binding kinase 1) Show summary » More detailed page go icon to follow link

References

Click here for help

Show »

How to cite this family page

Database page citation:

IKK family. Accessed on 13/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=578.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.