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TAO subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The human genome encodes three thousand and one amino acid (TAO) kinase genes. The enzymes regulate MAPK and Hippo signaling pathways and have pleiotropic functions, participating in a range of cellular processes including stress responses, cell proliferation, immune responses and neurodevelopment [1]. Whilst the N-terminal catalytic domains of the three TAOKs are conserved, divergent non-catalytic functions appear to be mediated by regulatory domains in the protein structures, Dysregulated activity has been associated with neurological disorders.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

TAO1 (TAO kinase 1) Show summary » More detailed page go icon to follow link

TAO2 (TAO kinase 2) Show summary » More detailed page go icon to follow link

TAO3 (TAO kinase 3) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

TAO subfamily. Accessed on 21/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=551.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.