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MST subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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MST1 (STK3) and MST2 (STK4) are the mammalian homologs of Drosophila Hippo (Hpo), and are core components of the Hippo pathway, which is a kinase cascade that regulates cell proliferation, survival, and migration and acts as a key regulator of organ growth and development and tissue homeostasis in multiple organisms [1-2].

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

MST2 (serine/threonine kinase 3) Show summary » More detailed page go icon to follow link

MST1 (serine/threonine kinase 4) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

MST subfamily. Accessed on 12/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=545.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.