MST subfamily
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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MST1 (STK3) and MST2 (STK4) are the mammalian homologs of Drosophila Hippo (Hpo), and are core components of the Hippo pathway, which is a kinase cascade that regulates cell proliferation, survival, and migration and acts as a key regulator of organ growth and development and tissue homeostasis in multiple organisms [1-2].
Enzymes
Targets of relevance to immunopharmacology are highlighted in blue
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MST2 (serine/threonine kinase 3)
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MST1 (serine/threonine kinase 4)
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How to cite this family page
Database page citation:
MST subfamily. Accessed on 25/07/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=545.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.
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