MSN subfamily

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Targets
Enzymes
Kinases (EC 2.7.x.x)
STE: Homologs of yeast Sterile 7, Sterile 11, Sterile 20 kinases
STE20 family
MSN subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

HGK (mitogen-activated protein kinase kinase kinase kinase 4) Show summary »« Hide summary More detailed page go icon to follow link

MINK (misshapen like kinase 1) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2103

Nomenclature

misshapen like kinase 1

Common abbreviation

MINK

Previous and unofficial names

Genes

MINK1 (Hs), Mink1 (Mm), Mink1 (Rn)

Ensembl ID

ENSG00000141503 (Hs), ENSMUSG00000020827 (Mm), ENSRNOG00000033508 (Rn)

UniProtKB AC

Q8N4C8 (Hs), Q9JM52 (Mm), F1LP90 (Rn)

EC number

2.7.11.1

NRK (Nik related kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2128

Nomenclature

Nik related kinase

Common abbreviation

NRK

Previous and unofficial names

Nck-interacting kinase-like embryo specific kinase | Nesk

Genes

NRK (Hs), Nrk (Mm), Nrk (Rn)

Ensembl ID

ENSG00000123572 (Hs), ENSMUSG00000052854 (Mm), ENSRNOG00000008880 (Rn)

UniProtKB AC

Q7Z2Y5 (Hs), Q9R0G8 (Mm)

EC number

2.7.11.1

TNIK (TRAF2 and NCK interacting kinase) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2244

Nomenclature

TRAF2 and NCK interacting kinase

Common abbreviation

TNIK

Genes

TNIK (Hs), Tnik (Mm), Tnik (Rn)

Ensembl ID

ENSG00000154310 (Hs), ENSMUSG00000027692 (Mm), ENSRNOG00000012422 (Rn)

UniProtKB AC

Q9UKE5 (Hs), P83510 (Mm)

EC number

2.7.11.1

Inhibitors

compound 5 [PMID: 23232060] pIC₅₀ 8.5 [2]

Comment

Tang et al. (2025) discovered that TNIK is senescence modulator, and that TNIK inhibition (using the TNIK inhibitor INS018_055 and siRNA-mediated TNIK knockdown) decreases cellular senescence across a range of experimental senescence models [3].

References

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1. Crawford TD, Ndubaku CO, Chen H, Boggs JW, Bravo BJ, Delatorre K, Giannetti AM, Gould SE, Harris SF, Magnuson SR et al.. (2014) Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization. J Med Chem, 57 (8): 3484-93. [PMID:24673130]

2. Ho KK, Parnell KM, Yuan Y, Xu Y, Kultgen SG, Hamblin S, Hendrickson TF, Luo B, Foulks JM, McCullar MV et al.. (2013) Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett, 23 (2): 569-73. [PMID:23232060]

3. Tang Q, Xiao D, Veviorskiy A, Xin Y, Lok SWY, Pulous FE, Zhang P, Zhu Y, Ma Y, Hu X et al.. (2025) AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent. Aging Dis, [Epub ahead of print]. [PMID:39965245]

How to cite this family page

Database page citation:

MSN subfamily. Accessed on 31/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=544.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.