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KHS subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian STE20-like family of serine/threonine kinases. Four members of the family (MAP4K1/HPK1, MAP4kK2/GCK, MAP4K3/GLK or KHS2 and MAP4K5/KHS1) are included in this KHS subfamily, whilst the fifth member (MAP4K4/HGK) resides in the MSN subfamily. The functions of the MAP4Ks in immunity and inflammation are reviewed by Chuang et al. (2016) [1].

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

HPK1 (mitogen-activated protein kinase kinase kinase kinase 1) Show summary » More detailed page go icon to follow link

GCK (mitogen-activated protein kinase kinase kinase kinase 2) Show summary » More detailed page go icon to follow link

KHS2 (mitogen-activated protein kinase kinase kinase kinase 3) Show summary » More detailed page go icon to follow link

KHS1 (mitogen-activated protein kinase kinase kinase kinase 5) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

KHS subfamily. Accessed on 12/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=543.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.