MSK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

MSK1 (ribosomal protein S6 kinase A5) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1523

Nomenclature

ribosomal protein S6 kinase A5

Common abbreviation

MSK1

Previous and unofficial names

Genes

RPS6KA5 (Hs), Rps6ka5 (Mm), Rps6ka5 (Rn)

Ensembl ID

ENSG00000100784 (Hs), ENSMUSG00000021180 (Mm), ENSRNOG00000004362 (Rn)

UniProtKB AC

O75582 (Hs), Q8C050 (Mm)

EC number

2.7.11.1

Inhibitors

SB-747651A pIC₅₀ 9.3 [1]

compound 24 [PMID: 15955699] pIC₅₀ 8.9 [1]

Comment

The mitogen- and stress-acted protein kinases are activated by phosphorylation evoked by MAP kinases and appear to be central to that pathway of cAMP response element-binding protein phosphorylation [2]

MSK2 (ribosomal protein S6 kinase A4) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1524

Nomenclature

ribosomal protein S6 kinase A4

Common abbreviation

MSK2

Previous and unofficial names

Genes

RPS6KA4 (Hs), Rps6ka4 (Mm), Rps6ka4 (Rn)

Ensembl ID

ENSG00000162302 (Hs), ENSMUSG00000118668 (Mm), ENSRNOG00000021117 (Rn)

UniProtKB AC

O75676 (Hs), Q9Z2B9 (Mm)

EC number

2.7.11.1

Comment

References

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How to cite this family page

Database page citation:

MSK subfamily. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=539.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.