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FRAP subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The protein product of the MTOR gene (previously been known as FK506-binding protein 12-rapamycin-associated protein 1; FRAP1) is the only member of this kinase subfamily. mTOR is the key enzymatic component of the TORC1 and TORC2 protein complexes. It can act as a Ser/Thr kinase (in both complexes) or a Tyr kinase (in TORC2). The clinically used drugs temsirolimus and everolimus inhibit mTOR kinase activity.

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

mTOR (mechanistic target of rapamycin kinase) C Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

FRAP subfamily. Accessed on 11/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=529.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.