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P2Y receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [1-2,41]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [12,26,39,70,73]. Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [53], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [14,65].

Receptors

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Targets of relevance to immunopharmacology are highlighted in blue

P2Y1 receptor C Show summary » More detailed page go icon to follow link

P2Y2 receptor C Show summary » More detailed page go icon to follow link

P2Y4 receptor C Show summary » More detailed page go icon to follow link

P2Y6 receptor C Show summary » More detailed page go icon to follow link

P2Y11 receptor C Show summary » More detailed page go icon to follow link

P2Y12 receptor C Show summary » More detailed page go icon to follow link

P2Y13 receptor C Show summary » More detailed page go icon to follow link

P2Y14 receptor C Show summary » More detailed page go icon to follow link

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 176 Suppl 1:S27-S156.