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CDK8 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CDK8 and CDK19 act as subunits of mammalian mediator complexes, which are essential regulators of RNA polymerase II transcriptional machinery [1]. CDK8 is also an oncogene and hence a molecular target for the developmet of novel anti-cancer therapeutics [2-4].


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Targets of relevance to immunopharmacology are highlighted in blue

CDK8 (cyclin dependent kinase 8) Show summary » More detailed page go icon to follow link

CDK19 (cyclin dependent kinase 19) Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

CDK8 subfamily. Accessed on 13/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.