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QIK subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Inhibition of SIKs is reported to promote a macrophage phenotype switch to a 'regulatory'-like phenotype [2-3], that favours resolution of inflammation. This action of SIKs provides a novel intervention point for pharmacological agents with potential as therapeutics for chronic inflammatory diseases.

Enzymes

Targets of relevance to immunopharmacology are highlighted in blue

SIK (salt inducible kinase 1) Show summary » More detailed page

QIK (salt inducible kinase 2) Show summary » More detailed page

QSK (SIK family kinase 3) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

QIK subfamily. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=483.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.