SLC51 family of steroid-derived molecule transporters | Transporters

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SLC superfamily of solute carriers
SLC51 family of steroid-derived molecule transporters

SLC51 family of steroid-derived molecule transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC51 organic solute transporter family of transporters is a pair of heterodimeric proteins which regulate bile salt movements in the small intestine, bile duct, and liver, as part of the enterohepatic circulation [1-2,4]. OSTα/OSTβ is also expressed in steroidogenic cells of the brain and adrenal gland, where it may contribute to steroid sulphate movement [5]. Bile acid and steroid sulphate transport is suggested to be facilitative and independent of sodium, potassium, chloride ions or protons [2,4]. OSTα/OSTβ heterodimers have been shown to transport [³H]taurocholic acid, [³H]dehydroepiandrosterone sulphate, [³H]estrone-3-sulphate, [³H]pregnenolone sulphate and [³H]dehydroepiandrosterone sulphate[2,4-5]. OSTα/OSTβ-mediated transport is inhibited by clofazimine and fidaxomicin [8,10]. OSTα is suggested to be a seven TM protein, while OSTβ is a single TM 'ancillary' protein, both of which are thought to have intracellular C-termini [7]. Both proteins function in solute transport [3,7]. Inherited mutations in OSTα and OSTβ are associated with liver disease and congenital diarrhea in children [6,9].

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

OSTα (Organic solute transporter subunit α / SLC51A1) C Show summary »« Hide summary

Target Id	1915
Nomenclature	Organic solute transporter subunit α
Systematic nomenclature	SLC51A1
Common abbreviation	OSTα
Previous and unofficial names	organic solute transporter subunit alpha \| solute carrier family 51, alpha subunit \| solute carrier family 51 \| solute carrier family 51 alpha subunit \| solute carrier family 51 subunit alpha
Genes	SLC51A (Hs), Slc51a (Mm), Slc51a (Rn)
Ensembl ID	ENSG00000163959 (Hs), ENSMUSG00000035699 (Mm), ENSRNOG00000001765 (Rn)
UniProtKB AC	Q86UW1 (Hs), Q8R000 (Mm)
Bioparadigms SLC Tables	SLC51A (Hs)
RESOLUTE	SLC51A (Hs)

OSTβ (Organic solute transporter subunit β / SLC51B) C Show summary »« Hide summary

Target Id	1916
Nomenclature	Organic solute transporter subunit β
Systematic nomenclature	SLC51B
Common abbreviation	OSTβ
Previous and unofficial names	organic solute transporter beta subunit \| solute carrier family 51, beta subunit \| solute carrier family 51 \| solute carrier family 51 beta subunit \| solute carrier family 51 subunit beta
Genes	SLC51B (Hs), Slc51b (Mm), Slc51b (Rn)
Ensembl ID	ENSG00000186198 (Hs), ENSMUSG00000053862 (Mm), ENSRNOG00000028889 (Rn)
UniProtKB AC	Q86UW2 (Hs), Q80WK2 (Mm)
Bioparadigms SLC Tables	SLC51B (Hs)
RESOLUTE	SLC51B (Hs)

References

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1. Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol, 176 Suppl 1: S397-S493. [PMID:31710713]

2. Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N. (2005) OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology, 42 (6): 1270-9. [PMID:16317684]

3. Christian WV, Li N, Hinkle PM, Ballatori N. (2012) β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. J Biol Chem, 287 (25): 21233-43. [PMID:22535958]

4. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N. (2005) The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem, 280 (8): 6960-8. [PMID:15563450]

5. Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N. (2010) Neurosteroid transport by the organic solute transporter OSTα-OSTβ. J Neurochem, 115 (1): 220-33. [PMID:20649839]

6. Gao E, Cheema H, Waheed N, Mushtaq I, Erden N, Nelson-Williams C, Jain D, Soroka CJ, Boyer JL, Khalil Y et al.. (2020) Organic Solute Transporter Alpha Deficiency: A Disorder With Cholestasis, Liver Fibrosis, and Congenital Diarrhea. Hepatology, 71 (5): 1879-1882. [PMID:31863603]

7. Li N, Cui Z, Fang F, Lee JY, Ballatori N. (2007) Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem J, 407 (3): 363-72. [PMID:17650074]

8. Malinen MM, Kauttonen A, Beaudoin JJ, Sjöstedt N, Honkakoski P, Brouwer KLR. (2019) Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β). Mol Pharm, 16 (1): 238-246. [PMID:30481467]

9. Sultan M, Rao A, Elpeleg O, Vaz FM, Abu-Libdeh B, Karpen SJ, Dawson PA. (2018) Organic solute transporter-β (SLC51B) deficiency in two brothers with congenital diarrhea and features of cholestasis. Hepatology, 68 (2): 590-598. [PMID:28898457]

10. van de Wiel SMW, de Waart DR, Oude Elferink RPJ, van de Graaf SFJ. (2018) Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β. Cell Mol Gastroenterol Hepatol, 5 (3): 223-237. [PMID:29675448]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.