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SLC50 sugar transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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A mouse stromal cell cDNA library was used to clone C2.3 [2], later termed Rag1-activating protein 1, with a sequence homology predictive of a 4TM topology. The plant orthologues, termed SWEETs, appear to be 7 TM proteins, with extracellular N-termini, and the capacity for bidirectional flux of D-glucose [1]. Expression of mouse SWEET in the mammary gland was suggestive of a role in Golgi lactose synthesis [1].


Targets of relevance to immunopharmacology are highlighted in blue

RAG1AP1 (SLC50 sugar exporter / SLC50A1) C Show summary »

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How to cite this family page

Database page citation:

SLC50 sugar transporter. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.