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SLC50 sugar transporter C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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A mouse stromal cell cDNA library was used to clone C2.3 [2], later termed Rag1-activating protein 1, with a sequence homology predictive of a 4TM topology. The plant orthologues, termed SWEETs, appear to be 7 TM proteins, with extracellular N-termini, and the capacity for bidirectional flux of D-glucose [1]. Expression of mouse SWEET in the mammary gland was suggestive of a role in Golgi lactose synthesis [1].

Transporters

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Targets of relevance to immunopharmacology are highlighted in blue

RAG1AP1 (SLC50 sugar exporter / SLC50A1) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC50 sugar transporter. Accessed on 06/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=336.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.