Type XIII RTKs: Ephrin receptor family | Catalytic receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

Type XIII RTKs: Ephrin receptor family C

Formerly known as: Ephrin receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Ephrin receptors are a family of 15 RTKs (the largest family of RTKs) with two identified subfamilies (EphA and EphB), which have a role in the regulation of neuronal development, cell migration, patterning and angiogenesis. Their ligands are membrane-associated proteins, thought to be glycosylphosphatidylinositol-linked for EphA (ephrin-A1 (EFNA1, P20827) , ephrin-A2 (EFNA2, O43921), ephrin-A3 (EFNA3, P52797), ephrin-A4 (EFNA4, P52798) and ephrin-A5 (EFNA5, P52803)) and 1TM proteins for Ephrin B (ENSFM00250000002014: ephrin-B1 (EFNB1, P98172), ephrin-B2 (EFNB2, P52799) and ephrin-B3 (EFNB3, Q15768)), although the relationship between ligands and receptors has been incompletely defined.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

EphA1 (EPH receptor A1) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1821

Nomenclature

EPH receptor A1

Common abbreviation

EphA1

Previous and unofficial names

EPHT1 | ephrin type-A receptor 1 | Embryonic stem cell kinase | tyrosine-protein kinase receptor ESK | Esk

Genes

EPHA1 (Hs), Epha1 (Mm), Epha1 (Rn)

Ensembl ID

ENSG00000146904 (Hs), ENSMUSG00000029859 (Mm), ENSRNOG00000017525 (Rn)

UniProtKB AC

P21709 (Hs), Q60750 (Mm)

EC number

2.7.10.1

EphA2 (EPH receptor A2) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1822

Nomenclature

EPH receptor A2

Common abbreviation

EphA2

Previous and unofficial names

Genes

EPHA2 (Hs), Epha2 (Mm), Epha2 (Rn)

Ensembl ID

ENSG00000142627 (Hs), ENSMUSG00000006445 (Mm), ENSRNOG00000009222 (Rn)

UniProtKB AC

P29317 (Hs), Q03145 (Mm)

EC number

2.7.10.1

EphA3 (EPH receptor A3) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1823

Nomenclature

EPH receptor A3

Common abbreviation

EphA3

Previous and unofficial names

ETK1 | HEK | HEK4 | EK4 | EPH-like kinase 4 | ephrin type-A receptor 3 | tyrosine-protein kinase receptor REK4 | tyrosine-protein kinase TYRO4 | End3 | Mek4

Genes

EPHA3 (Hs), Epha3 (Mm), Epha3 (Rn)

Ensembl ID

ENSG00000044524 (Hs), ENSMUSG00000052504 (Mm), ENSRNOG00000030285 (Rn)

UniProtKB AC

P29320 (Hs), P29319 (Mm), O08680 (Rn)

EC number

2.7.10.1

EphA4 (EPH receptor A4) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1824

Nomenclature

EPH receptor A4

Common abbreviation

EphA4

Previous and unofficial names

Hek8 | TYRO1 | Tyrosine-protein kinase receptor MPK-3 | Tyrosine-protein kinase receptor SEK-1

Genes

EPHA4 (Hs), Epha4 (Mm), Epha4 (Rn)

Ensembl ID

ENSG00000116106 (Hs), ENSMUSG00000026235 (Mm), ENSRNOG00000013213 (Rn)

UniProtKB AC

P54764 (Hs), Q03137 (Mm)

EC number

2.7.10.1

EphA5 (EPH receptor A5) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1825

Nomenclature

EPH receptor A5

Common abbreviation

EphA5

Previous and unofficial names

Genes

EPHA5 (Hs), Epha5 (Mm), Epha5 (Rn)

Ensembl ID

ENSG00000145242 (Hs), ENSMUSG00000029245 (Mm), ENSRNOG00000002024 (Rn)

UniProtKB AC

P54756 (Hs), Q60629 (Mm), P54757 (Rn)

EC number

2.7.10.1

EphA6 (EPH receptor A6) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1826

Nomenclature

EPH receptor A6

Common abbreviation

EphA6

Previous and unofficial names

EHK2 | EPH homology kinase 2 | ephrin type-A receptor 6 | tyrosine-protein kinase receptor EHK-2 | Hek12

Genes

EPHA6 (Hs), Epha6 (Mm), Epha6 (Rn)

Ensembl ID

ENSG00000080224 (Hs), ENSMUSG00000055540 (Mm), ENSRNOG00000029184 (Rn)

UniProtKB AC

Q9UF33 (Hs), Q62413 (Mm), P54758 (Rn)

EC number

2.7.10.1

EphA7 (EPH receptor A7) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1827

Nomenclature

EPH receptor A7

Common abbreviation

EphA7

Previous and unofficial names

HEK11 | EPH homology kinase 3 | ephrin type-A receptor 7 | tyrosine-protein kinase receptor EHK-3 | EBK | Embryonic brain kinase | MDK1

Genes

EPHA7 (Hs), Epha7 (Mm), Epha7 (Rn)

Ensembl ID

ENSG00000135333 (Hs), ENSMUSG00000028289 (Mm), ENSRNOG00000007030 (Rn)

UniProtKB AC

Q15375 (Hs), Q61772 (Mm), P54759 (Rn)

EC number

2.7.10.1

EphA8 (EPH receptor A8) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1828

Nomenclature

EPH receptor A8

Common abbreviation

EphA8

Previous and unofficial names

HEK3 | EPH- and ELK-related kinase | ephrin type-A receptor 8 | tyrosine-protein kinase receptor EEK

Genes

EPHA8 (Hs), Epha8 (Mm), Epha8 (Rn)

Ensembl ID

ENSG00000070886 (Hs), ENSMUSG00000028661 (Mm), ENSRNOG00000013036 (Rn)

UniProtKB AC

P29322 (Hs), O09127 (Mm), P29321 (Rn)

EC number

2.7.10.1

EphA10 (EPH receptor A10) C Show summary »« Hide summary More detailed page go icon to follow link

EphB1 (EPH receptor B1) C Show summary »« Hide summary More detailed page go icon to follow link

EphB2 (EPH receptor B2) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1831

Nomenclature

EPH receptor B2

Common abbreviation

EphB2

Previous and unofficial names

Genes

EPHB2 (Hs), Ephb2 (Mm), Ephb2 (Rn)

Ensembl ID

ENSG00000133216 (Hs), ENSMUSG00000028664 (Mm), ENSRNOG00000012531 (Rn)

UniProtKB AC

P29323 (Hs), P54763 (Mm)

EC number

2.7.10.1

EphB3 (EPH receptor B3) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1832

Nomenclature

EPH receptor B3

Common abbreviation

EphB3

Previous and unofficial names

Genes

EPHB3 (Hs), Ephb3 (Mm), Ephb3 (Rn)

Ensembl ID

ENSG00000182580 (Hs), ENSMUSG00000005958 (Mm), ENSRNOG00000031801 (Rn)

UniProtKB AC

P54753 (Hs), P54754 (Mm)

EC number

2.7.10.1

EphB4 (EPH receptor B4) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1833

Nomenclature

EPH receptor B4

Common abbreviation

EphB4

Previous and unofficial names

Genes

EPHB4 (Hs), Ephb4 (Mm)

Ensembl ID

ENSG00000196411 (Hs), ENSMUSG00000029710 (Mm)

UniProtKB AC

P54760 (Hs), P54761 (Mm)

EC number

2.7.10.1

Inhibitors

tesevatinib pIC₅₀ 8.9 [1]

EphB6 (EPH receptor B6) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1834

Nomenclature

EPH receptor B6

Common abbreviation

EphB6

Previous and unofficial names

ephrin type-B receptor 6 | tyrosine-protein kinase-defective receptor EPH-6 | MEP | Cekl

Genes

EPHB6 (Hs), Ephb6 (Mm), Ephb6 (Rn)

Ensembl ID

ENSG00000106123 (Hs), ENSMUSG00000029869 (Mm), ENSRNOG00000014367 (Rn)

UniProtKB AC

O15197 (Hs), O08644 (Mm), P0C0K7 (Rn)

EC number

2.7.10.1

References

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How to cite this family page

Database page citation:

Type XIII RTKs: Ephrin receptor family. Accessed on 15/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=327.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.