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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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More detailed introduction
Ephrin receptors are a family of 15 RTKs (the largest family of RTKs) with two identified subfamilies (EphA and EphB), which have a role in the regulation of neuronal development, cell migration, patterning and angiogenesis. Their ligands are membrane-associated proteins, thought to be glycosylphosphatidylinositol-linked for EphA (ephrin-A1 (EFNA1, P20827) , ephrin-A2 (EFNA2, O43921), ephrin-A3 (EFNA3, P52797), ephrin-A4 (EFNA4, P52798) and ephrin-A5 (EFNA5, P52803)) and 1TM proteins for Ephrin B (ENSFM00250000002014: ephrin-B1 (EFNB1, P98172), ephrin-B2 (EFNB2, P52799) and ephrin-B3 (EFNB3, Q15768)), although the relationship between ligands and receptors has been incompletely defined.
EphA1 (EPH receptor A1) C
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EphA2 (EPH receptor A2) C
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EphA3 (EPH receptor A3) C
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EphA4 (EPH receptor A4)
C
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EphA5 (EPH receptor A5) C
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EphA6 (EPH receptor A6) C
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EphA7 (EPH receptor A7) C
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EphA8 (EPH receptor A8) C
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EphA10 (EPH receptor A10) C
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EphB1 (EPH receptor B1) C
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EphB2 (EPH receptor B2) C
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EphB3 (EPH receptor B3) C
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EphB4 (EPH receptor B4) C
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EphB6 (EPH receptor B6) C
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Database page citation:
Type XIII RTKs: Ephrin receptor family. Accessed on 18/06/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=327.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.