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Type II receptor serine/threonine kinases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The type II protein phosphorylates the kinase domain of the type I partner (sometimes referred to as the signal propagating subunit), causing displacement of the protein partners, such as the FKBP12 FK506-binding protein FKBP1A (P62942) and allowing the binding and phosphorylation of particular members of the Smad family.

Receptors

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Targets of relevance to immunopharmacology are highlighted in blue

ActR2 (activin A receptor type 2A) C Show summary » More detailed page go icon to follow link

ActR2B (activin A receptor type 2B) C Show summary » More detailed page go icon to follow link

MISR2 (anti-Mullerian hormone receptor type 2) C Show summary » More detailed page go icon to follow link

BMPR2 (bone morphogenetic protein receptor type 2) C Show summary » More detailed page go icon to follow link

TGFBR2 (transforming growth factor beta receptor 2) C Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Type II receptor serine/threonine kinases. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=319.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Catalytic receptors. Br J Pharmacol. 176 Suppl 1: S247-S296.