Top ▲

Akt (Protein kinase B, PKB) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


« Hide

The action of phosphatidylinositol 3-kinase (PI3K), a downstream kinase activated by receptor tyrosine kinases, produces a series of phosphorylated phosphoinositides, which recruit 3-phosphoinositide-dependent kinase (PDPK1, O15530) activity to the plasma membrane, leading to activation of Akt. Akt may be activated by PIP3, PDK1-mediated phosphorylation [1] and mTORC2-mediated phosphorylation [6,11].


Targets of relevance to immunopharmacology are highlighted in blue

Akt1 (AKT serine/threonine kinase 1) Show summary » More detailed page

Akt2 (AKT serine/threonine kinase 2) Show summary » More detailed page

AKT3 (AKT serine/threonine kinase 3) Show summary » More detailed page


Show »

How to cite this family page

Database page citation:

Akt (Protein kinase B, PKB) family. Accessed on 18/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.