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Akt (Protein kinase B, PKB) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The action of phosphatidylinositol 3-kinase (PI3K), a downstream kinase activated by receptor tyrosine kinases, produces a series of phosphorylated phosphoinositides, which recruit 3-phosphoinositide-dependent kinase (PDPK1, O15530) activity to the plasma membrane, leading to activation of Akt. Akt may be activated by PIP3, PDK1-mediated phosphorylation [1] and mTORC2-mediated phosphorylation [6,11].

Enzymes

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Targets of relevance to immunopharmacology are highlighted in blue

Akt1 (AKT serine/threonine kinase 1) Show summary » More detailed page go icon to follow link

Akt2 (AKT serine/threonine kinase 2) Show summary » More detailed page go icon to follow link

AKT3 (AKT serine/threonine kinase 3) Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Akt (Protein kinase B, PKB) family. Accessed on 16/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=285.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.