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SLC45 family of putative sugar transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Members of the SLC45 family remain to be fully characterised. SLC45A1 was initially identified in the rat brain, particularly predominant in the hindbrain, as a proton-associated sugar transport, induced by hypercapnia [3]. The protein is predicted to have 12TM domains, with intracellular termini. The SLC45A2 gene is thought to encode a transporter protein that mediates melanin synthesis. Mutations in SLC45A2 are a cause of oculocutaneous albinism type 4 (e.g. [2]), and polymorphisms in this gene are associated with variations in skin and hair color (e.g. [1]).


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Targets of relevance to immunopharmacology are highlighted in blue

Proton-associated sugar transporter A / SLC45A1 C Show summary »

Target Id 1209
Nomenclature Proton-associated sugar transporter A
Systematic nomenclature SLC45A1
Previous and unofficial names DNB5 | deleted in neuroblastoma 5 | Pasta | Past-A | solute carrier family 45, member 1 | solute carrier family 45
Genes SLC45A1 (Hs), Slc45a1 (Mm), Slc45a1 (Rn)
Ensembl ID ENSG00000162426 (Hs), ENSMUSG00000039838 (Mm), ENSRNOG00000018229 (Rn)
UniProtKB AC Q9Y2W3 (Hs), Q8BIV7 (Mm), Q8K4S3 (Rn)
Bioparadigms SLC Tables SLC45A1 (Hs)
L-glucose Rat [3]
Galactose Rat [3]
Stoichiometry Unknown; increased at acid pH [3].

Membrane-associated transporter protein / SLC45A2 Show summary »

Solute carrier family 45 member 3 / SLC45A3 Show summary »

Solute carrier family 45 member 4 / SLC45A4 Show summary »

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How to cite this family page

Database page citation:

SLC45 family of putative sugar transporters. Accessed on 07/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.