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SLC41 family of divalent cation transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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By analogy with bacterial orthologues, this family is probably magnesium transporters. The prokaryote orthologue, MgtE, is responsible for uptake of divalent cations, while the heterologous expression studies of mammalian proteins suggest Mg2+ efflux [3], possibly as a result of co-expression of particular protein partners (see [4]). Topological modelling suggests 10 TM domains with cytoplasmic C- and N- termini.


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Targets of relevance to immunopharmacology are highlighted in blue

MgtE (Solute carrier family 41 member 1 / SLC41A1) C Show summary »

Target Id 1195
Nomenclature Solute carrier family 41 member 1
Systematic nomenclature SLC41A1
Common abbreviation MgtE
Previous and unofficial names solute carrier family 41 (magnesium transporter), member 1 | solute carrier family 41
Genes SLC41A1 (Hs), Slc41a1 (Mm), Slc41a1 (Rn)
Ensembl ID ENSG00000133065 (Hs), ENSMUSG00000013275 (Mm), ENSRNOG00000042320 (Rn)
UniProtKB AC Q8IVJ1 (Hs), Q8BJA2 (Mm)
Bioparadigms SLC Tables SLC41A1 (Hs)
Zn2+ [1]
Mg2+ [1]
Ba2+ [1]
Cd2+ [1]
Co2+ [1]
Cu2+ [1]
Fe2+ [1]
Sr2+ [1]
Stoichiometry Unknown

Solute carrier family 41 member 2 / SLC41A2 C Show summary »

Solute carrier family 41 member 3 / SLC41A3 Show summary »

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How to cite this family page

Database page citation:

SLC41 family of divalent cation transporters. Accessed on 18/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.