Orphan SLC38 transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC38 family of sodium-dependent neutral amino acid transporters
Orphan SLC38 transporters

Orphan SLC38 transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

SNAT6 (Probable sodium-coupled neutral amino acid transporter 6 / SLC38A6) Show summary »« Hide summary

Target Id	1174
Nomenclature	Probable sodium-coupled neutral amino acid transporter 6
Systematic nomenclature	SLC38A6
Common abbreviation	SNAT6
Previous and unofficial names	NAT-1 \| Na+-dependent neutral amino acid transporter \| N-system amino acid transporter 1 \| solute carrier family 38, member 6 \| solute carrier family 38
Genes	SLC38A6 (Hs), Slc38a6 (Mm), Slc38a6 (Rn)
Ensembl ID	ENSG00000139974 (Hs), ENSMUSG00000044712 (Mm), ENSRNOG00000022622 (Rn)
UniProtKB AC	Q8IZM9 (Hs), Q6WWW3 (Rn)
Bioparadigms SLC Tables	SLC38A6 (Hs)
RESOLUTE	SLC38A6 (Hs)

SNAT7 (Putative sodium-coupled neutral amino acid transporter 7 / SLC38A7) C Show summary »« Hide summary

Target Id	1175
Nomenclature	Putative sodium-coupled neutral amino acid transporter 7
Systematic nomenclature	SLC38A7
Common abbreviation	SNAT7
Previous and unofficial names	solute carrier family 38, member 7 \| solute carrier family 38
Genes	SLC38A7 (Hs), Slc38a7 (Mm), Slc38a7 (Rn)
Ensembl ID	ENSG00000103042 (Hs), ENSMUSG00000036534 (Mm), ENSRNOG00000012007 (Rn)
UniProtKB AC	Q9NVC3 (Hs), Q8BWH0 (Mm), Q6JWR2 (Rn)
Bioparadigms SLC Tables	SLC38A7 (Hs)
RESOLUTE	SLC38A7 (Hs)
Comment	SNAT7/SLC38A7 has been described to be a system N-like transporter allowing preferential accumulation of glutamine (e.g. L-glutamine), histidine (e.g. L-histidine) and asparagine (e.g. L-asparagine) [1].

Putative sodium-coupled neutral amino acid transporter 8 / SLC38A8 Show summary »« Hide summary

Target Id	1176
Nomenclature	Putative sodium-coupled neutral amino acid transporter 8
Systematic nomenclature	SLC38A8
Previous and unofficial names	solute carrier family 38, member 8 \| solute carrier family 38
Genes	SLC38A8 (Hs), Slc38a8 (Mm), Slc38a8 (Rn)
Ensembl ID	ENSG00000166558 (Hs), ENSMUSG00000034224 (Mm), ENSRNOG00000025503 (Rn)
UniProtKB AC	A6NNN8 (Hs), Q5HZH7 (Mm)
Bioparadigms SLC Tables	SLC38A8 (Hs)
RESOLUTE	SLC38A8 (Hs)

Putative sodium-coupled neutral amino acid transporter 9 / SLC38A9 Show summary »« Hide summary

Target Id	1177
Nomenclature	Putative sodium-coupled neutral amino acid transporter 9
Systematic nomenclature	SLC38A9
Previous and unofficial names	solute carrier family 38, member 9 \| solute carrier family 38
Genes	SLC38A9 (Hs), Slc38a9 (Mm), Slc38a9 (Rn)
Ensembl ID	ENSG00000177058 (Hs), ENSMUSG00000047789 (Mm), ENSRNOG00000009851 (Rn)
UniProtKB AC	Q8NBW4 (Hs), Q8BGD6 (Mm), Q3B8Q3 (Rn)
Bioparadigms SLC Tables	SLC38A9 (Hs)
RESOLUTE	SLC38A9 (Hs)
Comment	One report has identified SLC38A9 as a functional component of the lysosomal amino acid sensing machinery involved in control of mTORC1 activity underlying the regulation of metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels [2].

PP1744 (Putative sodium-coupled neutral amino acid transporter 10 / SLC38A10) Show summary »« Hide summary

Target Id	1178
Nomenclature	Putative sodium-coupled neutral amino acid transporter 10
Systematic nomenclature	SLC38A10
Common abbreviation	PP1744
Previous and unofficial names	solute carrier family 38, member 10 \| solute carrier family 38
Genes	SLC38A10 (Hs), Slc38a10 (Mm), Slc38a10 (Rn)
Ensembl ID	ENSG00000157637 (Hs), ENSMUSG00000061306 (Mm), ENSRNOG00000004604 (Rn)
UniProtKB AC	Q9HBR0 (Hs), Q5I012 (Mm)
Bioparadigms SLC Tables	SLC38A10 (Hs)
RESOLUTE	SLC38A10 (Hs)

AVT2 (Putative sodium-coupled neutral amino acid transporter 11 / SLC38A11) Show summary »« Hide summary

Target Id	1179
Nomenclature	Putative sodium-coupled neutral amino acid transporter 11
Systematic nomenclature	SLC38A11
Common abbreviation	AVT2
Previous and unofficial names	AVT2 \| solute carrier family 38, member 11 \| solute carrier family 38
Genes	SLC38A11 (Hs), Slc38a11 (Mm), Slc38a11 (Rn)
Ensembl ID	ENSG00000169507 (Hs), ENSMUSG00000061171 (Mm), ENSRNOG00000004966 (Rn)
UniProtKB AC	Q08AI6 (Hs), Q3USY0 (Mm)
Bioparadigms SLC Tables	SLC38A11 (Hs)
RESOLUTE	SLC38A11 (Hs)

References

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How to cite this family page

Database page citation:

Orphan SLC38 transporters. Accessed on 14/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=227.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.