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SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.

Transporters

1165
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Targets of relevance to immunopharmacology are highlighted in blue

SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »


Target Id 1165
Nomenclature Glycerol-3-phosphate transporter
Systematic nomenclature SLC37A1
Common abbreviation SPX1
Previous and unofficial names G3PP | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | solute carrier family 37 (glycerol-3-phosphate transporter)
Genes SLC37A1 (Hs), Slc37a1 (Mm), Slc37a1 (Rn)
Ensembl ID ENSG00000160190 (Hs), ENSMUSG00000024036 (Mm), ENSRNOG00000001169 (Rn)
UniProtKB AC P57057 (Hs)
Bioparadigms SLC Tables SLC37A1 (Hs)
RESOLUTE SLC37A1 (Hs)
Endogenous substrates
glucose 6-phosphate
glycerol 3-phosphate
Stoichiometry Glucose 6-phosphate (in): phosphate (out) [4].

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=224.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.