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SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.


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Targets of relevance to immunopharmacology are highlighted in blue

SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »

Target Id 1165
Nomenclature Glycerol-3-phosphate transporter
Systematic nomenclature SLC37A1
Common abbreviation SPX1
Previous and unofficial names G3PP | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | solute carrier family 37 (glycerol-3-phosphate transporter)
Genes SLC37A1 (Hs), Slc37a1 (Mm), Slc37a1 (Rn)
Ensembl ID ENSG00000160190 (Hs), ENSMUSG00000024036 (Mm), ENSRNOG00000001169 (Rn)
UniProtKB AC P57057 (Hs)
Bioparadigms SLC Tables SLC37A1 (Hs)
Endogenous substrates
glucose 6-phosphate
glycerol 3-phosphate
Stoichiometry Glucose 6-phosphate (in): phosphate (out) [4].

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »

Further reading

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How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.