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SLC37 family of phosphosugar/phosphate exchangers C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The family of sugar-phosphate exchangers pass particular phosphorylated sugars across intracellular membranes, exchanging for inorganic phosphate. Of the family of sugar phosphate transporters, most information is available on SPX4, the glucose-6-phosphate transporter. This is a 10 TM domain protein with cytoplasmic termini and is associated with the endoplasmic reticulum, with tissue-specific splice variation.

Transporters

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Targets of relevance to immunopharmacology are highlighted in blue

SPX1 (Glycerol-3-phosphate transporter / SLC37A1) C Show summary »

SPX2 (Sugar phosphate exchanger 2 / SLC37A2) C Show summary »

SPX3 (Sugar phosphate exchanger 3 / SLC37A3) Show summary »

SPX4 (Glucose-6-phosphate transporter / SLC37A4) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC37 family of phosphosugar/phosphate exchangers. Accessed on 06/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=224.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.