Top ▲

SLC36 family of proton-coupled amino acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Members of the SLC36 family of proton-coupled amino acid transporters are involved in membrane transport of amino acids and derivatives [28-29]. The four transporters show variable tissue expression patterns and are expressed in various cell types at the plasma-membrane and in intracellular organelles. PAT1 is expressed at the luminal surface of the small intestine and absorbs amino acids and derivatives [4]. In lysosomes, PAT1 functions as an efflux mechanism for amino acids produced during intralysosomal proteolysis [2,25]. PAT2 is expressed at the apical membrane of the renal proximal tubule [7] and at the plasma-membrane in brown/beige adipocytes [30]. PAT1 and PAT4 are involved in regulation of the mTORC1 pathway [11,27]. More comprehensive lists of substrates can be found within the reviews under Further Reading and in the references [3].

Transporters

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

PAT1 (Proton-coupled Amino acid Transporter 1 / SLC36A1) C Show summary »

PAT2 (Proton-coupled Amino acid Transporter 2 / SLC36A2) C Show summary »

PAT3 (Proton-coupled Amino acid Transporter 3 / SLC36A3) C Show summary »

PAT4 (Proton-coupled Amino acid Transporter 4 / SLC36A4) C Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.