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SLC27 family of fatty acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fatty acid transporter proteins (FATPs) are a family (SLC27) of six transporters (FATP1-6). They have at least one, and possibly six [5,11], transmembrane segments, and are predicted on the basis of structural similarities to form dimers. SLC27 members have several structural domains: integral membrane associated domain, peripheral membrane associated domain, FATP signature, intracellular AMP binding motif, dimerization domain, lipocalin motif, and an ER localization domain (identified in FATP4 only) [3,8-9]. These transporters are unusual in that they appear to express intrinsic very long-chain acyl-CoA synthetase (EC 6.2.1.- , EC 6.2.1.7) enzyme activity. Within the cell, these transporters may associate with plasma and peroxisomal membranes. FATP1-4 and -6 transport long- and very long-chain fatty acids, while FATP5 transports long-chain fatty acids as well as bile acids [1,7,11].

Transporters

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Targets of relevance to immunopharmacology are highlighted in blue

FATP1 (Fatty acid transport protein 1 / SLC27A1) C Show summary » More detailed page go icon to follow link

FATP2 (Fatty acid transport protein 2 / SLC27A2) C Show summary »

FATP3 (Fatty acid transport protein 3 / SLC27A3) C Show summary »

FATP4 (Fatty acid transport protein 4 / SLC27A4) C Show summary »

FATP5 (Fatty acid transport protein 5 / SLC27A5) C Show summary »

FATP6 (Fatty acid transport protein 6 / SLC27A6) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.