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Mitochondrial nucleotide transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial nucleotide transporters, defined by structural similarlities, include the adenine nucleotide translocator family (SLC25A4, SLC25A5, SLC25A6 and SLC25A31), which under conditions of aerobic metabolism, allow coupling between mitochondrial oxidative phosphorylation and cytosolic energy consumption by exchanging cytosolic ADP for mitochondrial ATP. Further members of the mitochondrial nucleotide transporter subfamily convey diverse substrates including CoA, although not all members have had substrates identified.

Transporters

1072
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Targets of relevance to immunopharmacology are highlighted in blue

ANT1 (Mitochondrial adenine nucleotide translocator 1 / SLC25A4) C Show summary »

ANT2 (Mitochondrial adenine nucleotide translocator 2 / SLC25A5) C Show summary »

ANT3 (Mitochondrial adenine nucleotide translocator 3 / SLC25A6) C Show summary »

ANT4 (Mitochondrial adenine nucleotide translocator 4 / SLC25A31) C Show summary »

GDC (Graves disease carrier / SLC25A16) C Show summary »

PMP34 (Peroxisomal membrane protein / SLC25A17) C Show summary »


Target Id 1072
Nomenclature Peroxisomal membrane protein
Systematic nomenclature SLC25A17
Common abbreviation PMP34
Previous and unofficial names peroxisomal membrane protein (34kD) | peroxisomal membrane protein PMP34 | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A17 (Hs), Slc25a17 (Mm), Slc25a17 (Rn)
Ensembl ID ENSG00000100372 (Hs), ENSMUSG00000022404 (Mm), ENSRNOG00000018920 (Rn)
UniProtKB AC O43808 (Hs), O70579 (Mm)
Bioparadigms SLC Tables SLC25A17 (Hs)
Substrates
ADP
ATP
adenosine 5'-monophosphate
Stoichiometry ATP (in)

DNC (Deoxynucleotide carrier 1 / SLC25A19) C Show summary »

SAMC1 (S-Adenosylmethionine carrier / SLC25A26) C Show summary »

SLC25A42 Show summary »

APC1 (Mitochondrial phosphate carrier 1 / SLC25A24) C Show summary »

APC2 (Mitochondrial phosphate carrier 2 / SLC25A23) C Show summary »

APC3 (Mitochondrial phosphate carrier 3 / SLC25A25) C Show summary »

MFTC (MFT / SLC25A32) Show summary »

PNC1 / SLC25A33 Show summary »

PNC2 (SLC25A36) Show summary »

SCaMC-3L / SLC25A41 Show summary »

SLC25A43 Show summary »

How to cite this family page

Database page citation:

Mitochondrial nucleotide transporter subfamily. Accessed on 19/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=206.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.