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Mitochondrial di- and tri-carboxylic acid transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Mitochondrial di- and tri-carboxylic acid transporters are grouped on the basis of commonality of substrates and include the citrate transporter which facilitates citric acid export from the mitochondria to allow the generation of oxalacetic acid and acetyl CoA through the action of ATP:citrate lyase.

Transporters

1052
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Targets of relevance to immunopharmacology are highlighted in blue

CIC (Mitochondrial citrate transporter / SLC25A1) C Show summary »

DIC (Mitochondrial dicarboxylate transporter / SLC25A10) C Show summary »


Target Id 1052
Nomenclature Mitochondrial dicarboxylate transporter
Systematic nomenclature SLC25A10
Common abbreviation DIC
Previous and unofficial names DIC1 | mitochondrial dicarboxylate carrier | solute carrier family 25 (mitochondrial carrier; decarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 | solute carrier family 25 (mitochondrial carrier
Genes SLC25A10 (Hs), Slc25a10 (Mm), Slc25a10 (Rn)
Ensembl ID ENSG00000183048 (Hs), ENSMUSG00000025792 (Mm), ENSRNOG00000036693 (Rn)
UniProtKB AC Q9UBX3 (Hs), Q9QZD8 (Mm)
Bioparadigms SLC Tables SLC25A10 (Hs)
RESOLUTE SLC25A10 (Hs)
Substrates
malic acid
succinic acid
phosphate
SO42-
S2O32-
Stoichiometry PO34- (in) : malate2- (out)

OGC (Mitochondrial oxoglutarate carrier / SLC25A11) C Show summary »

ODC (Mitochondrial oxodicarboxylate carrier / SLC25A21) C Show summary »

SLC25A34 Show summary »

SLC25A35 Show summary »

How to cite this family page

Database page citation:

Mitochondrial di- and tri-carboxylic acid transporter subfamily. Accessed on 08/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=203.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.