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SLC20 family of sodium-dependent phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC20 family is looked upon not only as ion transporters, but also as retroviral receptors. As ion transporters, they are sometimes referred to as Type III sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type II (SLC34 family). PiTs are cell-surface transporters, composed of ten TM domains with extracellular C- and N-termini. PiT1 is a focus for dietary phosphate and vitamin D regulation of parathyroid hormone secretion from the parathyroid gland. PiT2 appears to be involved in intestinal absorption of dietary phosphate.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

PiT1 (Sodium-dependent phosphate transporter 1 / SLC20A1) C Show summary »

PiT2 (Sodium-dependent phosphate transporter 2 / SLC20A2) C Show summary »

Further reading

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References

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How to cite this family page

Database page citation:

SLC20 family of sodium-dependent phosphate transporters. Accessed on 17/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=195.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.