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SLC19 family of vitamin transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The B vitamins folic acid and thiamine are transported across the cell membrane, particularly in the intestine, kidneys and placenta, using pH differences as driving forces. Topological modelling suggests the transporters have 12 TM domains.

Transporters

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Targets of relevance to immunopharmacology are highlighted in blue

FOLT (Reduced folate transporter 1 / SLC19A1) C Show summary »

ThTr1 (Thiamine transporter 1 / SLC19A2) C Show summary »

ThTr2 (Thiamine transporter 2 / SLC19A3) C Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC19 family of vitamin transporters. Accessed on 28/11/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=194.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.