Type I sodium-phosphate co-transporters | Transporters | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

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SLC superfamily of solute carriers
SLC17 phosphate and organic anion transporter family
Type I sodium-phosphate co-transporters

Type I sodium-phosphate co-transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Type I sodium-phosphate co-transporters are expressed in the kidney and intestine.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

NPT1 (Sodium/phosphate cotransporter 1 / SLC17A1) C Show summary »« Hide summary

Target Id

1002

Nomenclature

Sodium/phosphate cotransporter 1

Systematic nomenclature

SLC17A1

Common abbreviation

NPT1

Previous and unofficial names

NaPi-1 | solute carrier family 17 (sodium phosphate), member 1 | renal sodium-dependent phosphate transport protein 1 | renal sodium-phosphate transport protein 1 | solute carrier family 17 (organic anion transporter), member 1 | solute carrier family 17 (sodium phosphate)

Genes

SLC17A1 (Hs), Slc17a1 (Mm), Slc17a1 (Rn)

Ensembl ID

ENSG00000124568 (Hs), ENSMUSG00000021335 (Mm), ENSRNOG00000042692 (Rn)

UniProtKB AC

Q14916 (Hs), Q61983 (Mm), Q62795 (Rn)

Bioparadigms SLC Tables

SLC17A1 (Hs)

RESOLUTE

SLC17A1 (Hs)

Substrates

Cl^- [2]

probenecid [1]

uric acid [2]

penicillin G [1]

organic acids [2]

phosphate [2]

Stoichiometry

Unknown

NPT3 (Sodium/phosphate cotransporter 3 / SLC17A2) C Show summary »« Hide summary

Target Id	1003
Nomenclature	Sodium/phosphate cotransporter 3
Systematic nomenclature	SLC17A2
Common abbreviation	NPT3
Previous and unofficial names	sodium-dependent phosphate transport protein 3 \| solute carrier family 17 (sodium phosphate), member 2 \| solute carrier family 17, member 2 \| solute carrier family 17 \| solute carrier family 17 (sodium phosphate)
Genes	SLC17A2 (Hs), Slc17a2 (Mm), Slc17a2 (Rn)
Ensembl ID	ENSG00000112337 (Hs), ENSMUSG00000036110 (Mm), ENSRNOG00000017180 (Rn)
UniProtKB AC	O00624 (Hs), Q5SZA1 (Mm)
Bioparadigms SLC Tables	SLC17A2 (Hs)
RESOLUTE	SLC17A2 (Hs)
Stoichiometry	Unknown

NPT4 (Sodium/phosphate cotransporter 4 / SLC17A3) C Show summary »« Hide summary

Target Id	1004
Nomenclature	Sodium/phosphate cotransporter 4
Systematic nomenclature	SLC17A3
Common abbreviation	NPT4
Previous and unofficial names	sodium-dependent phosphate transport protein 4 \| solute carrier family 17 (sodium phosphate), member 3 \| solute carrier family 17 (organic anion transporter), member 3 \| solute carrier family 17 (sodium phosphate)
Genes	SLC17A3 (Hs), Slc17a3 (Mm), Slc17a3 (Rn)
Ensembl ID	ENSG00000124564 (Hs), ENSMUSG00000036083 (Mm), ENSRNOG00000032745 (Rn)
UniProtKB AC	O00476 (Hs)
Bioparadigms SLC Tables	SLC17A3 (Hs)
RESOLUTE	SLC17A3 (Hs)
Stoichiometry	Unknown

Sodium/phosphate cotransporter homolog / SLC17A4 C Show summary »« Hide summary

Target Id	1005
Nomenclature	Sodium/phosphate cotransporter homolog
Systematic nomenclature	SLC17A4
Previous and unofficial names	solute carrier family 17 (sodium phosphate), member 4 \| solute carrier family 17, member 4 \| solute carrier family 17 \| solute carrier family 17 (sodium phosphate)
Genes	SLC17A4 (Hs), Slc17a4 (Mm), Slc17a4 (Rn)
Ensembl ID	ENSG00000146039 (Hs), ENSMUSG00000021336 (Mm), ENSRNOG00000022505 (Rn)
UniProtKB AC	Q9Y2C5 (Hs), Q5NCM1 (Mm)
Bioparadigms SLC Tables	SLC17A4 (Hs)
RESOLUTE	SLC17A4 (Hs)
Stoichiometry	Unknown

References

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How to cite this family page

Database page citation:

Type I sodium-phosphate co-transporters. Accessed on 29/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=189.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Transporters. Br J Pharmacol. 182: S404-S496.