Top ▲

SLC11 family of proton-coupled metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The family of proton-coupled metal ion transporters are responsible for movements of divalent cations, particularly ferrous and manganese ions, across the cell membrane (SLC11A2/DMT1) and across endosomal (SLC11A2/DMT1) or lysosomal/phagosomal membranes (SLC11A1/NRAMP1), dependent on proton transport. Both proteins appear to have 12 TM regions and cytoplasmic N- and C- termini. NRAMP1 is involved in antimicrobial action in macrophages, although its precise mechanism is undefined. Facilitated diffusion of divalent cations into phagosomes may increase intravesicular free radicals to damage the pathogen. Alternatively, export of divalent cations from the phagosome may deprive the pathogen of essential enzyme cofactors. SLC11A2/DMT1 is more widely expressed and appears to assist in divalent cation assimilation from the diet, as well as in phagocytotic cells.


Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

NRAMP1 / SLC11A1 C Show summary » More detailed page go icon to follow link

DMT1 / SLC11A2 C Show summary »

Target Id 967
Nomenclature DMT1
Systematic nomenclature SLC11A2
Previous and unofficial names DCT1 | Natural resistance-associated macrophage protein 2 | NRAMP2 | divalent cation transporter 1 | divalent metal transporter 1 | Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2) | van | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | solute carrier family 11 (proton-coupled divalent metal ion transporters)
Genes SLC11A2 (Hs), Slc11a2 (Mm), Slc11a2 (Rn)
Ensembl ID ENSG00000110911 (Hs), ENSMUSG00000023030 (Mm), ENSRNOG00000019550 (Rn)
UniProtKB AC P49281 (Hs), P49282 (Mm), O54902 (Rn)
Bioparadigms SLC Tables SLC11A2 (Hs)
Endogenous substrates
compound 6b [PMID: 22749870] pIC50 7.1 [2]
Stoichiometry 1 H+ : 1 Fe2+ (out) [1]


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

SLC11 family of proton-coupled metal ion transporters. Accessed on 18/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.